| Comments |
P.1 bottom paragraph: "Until quite recently, most known examples of novel peptide sequences were intimately related to a pre-existing gene, usually being an extension of coding sequence into an intron or UTR, or, more radically, translating an alternative reading frame of the mRNA in so-called ‘overprinting’ [refs 8,11–15]. However, it has now become clear that de novo origin of protein-coding genes from non-coding DNA is a consistent feature of eukaryotic genomes, having been discovered in organisms as diverse as yeast, plants, flies, mammals, primates and even in recent human evolution (table 1)." P.3 left column bottom paragraph: "The numbers of genes detected vary quite widely from study to study with very little overlap (table 1)." |