Cellular concentrations of key proteins in the actin system of diverse cells

Range Table - link μM
Organism Eukaryotes
Reference Pollard TD, Blanchoin L, Mullins RD. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct. 2000 29: 545-76. p.549 table 1PubMed ID10940259
Primary Source See pointers to refs beneath table
Comments P.549 bottom paragraph: "This is a minimal model with just 5 of the >60 families of actin-binding proteins (ref 101). [Investigators] focus on these proteins (profilin and thymosin-β4, Arp2/3 complex, capping protein, and ADF/cofilin), because they are highly conserved, well characterized, and sufficient to induce self-sustaining assembly of dynamic actin filament networks that drive motility of pathogenic, intracellular bacteria (ref 63). Most eukaryotic cells use the same abundant set of cytoskeletal proteins to construct pseudopods (Table 1). Yeasts have similar proteins in dynamic actin patches. Because the building blocks, the overall structure, and (probably) the mechanism of assembly are so highly conserved, [they] regard the leading edge of a motile cell as a discrete cytoskeletal structure, one whose function and design principles were specified early in eukaryotic evolution."
Entered by Uri M
ID 109981