| Range |
mouse Hopx 73 aa: C. elegans CEH-7 84 aa: Arabidopsis Ringlet 1 1,705 aa: human ZFHX3 3,703 aa
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| Organism |
Eukaryotes |
| Reference |
Bürglin TR, Affolter M. Homeodomain proteins: an update. Chromosoma. 2016 Jun125(3):497-521. doi: 10.1007/s00412-015-0543-8 p.499 right column bottom paragraphPubMed ID26464018
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| Primary Source |
Kook H et al., Analysis of the structure and function of the transcriptional coregulator HOP. Biochemistry. 2006 Sep 5 45(35):10584-90 DOI: 10.1021/bi060641s AND Kagoshima H, Cassata G, Bürglin TR. A Caenorhabditis elegans homeobox gene expressed in the male tail, a link between pattern formation and sexual dimorphism? Dev Genes Evol. 1999 Jan209(1):59-62PubMed ID16939210, 9914419
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| Method |
Primary source Kook et al., 2006 abstract: "To work toward an understanding of HOP (Homeodomain-only protein) function, [investigators] have determined the 3D structure of full-length HOP and used a range of biochemical assays to define the parts of the protein that are functionally important for its repression activity." Primary source Kagoshima et al., 1999 abstract: "ceh-7 is a small Caenorhabditis elegans homeobox gene. [Investigators] have shown that this gene is transcribed. Examination of the expression pattern of ceh-7 using reporter constructs revealed that it is expressed in a few cells of the male tail, which form a ring around the rectum." |
| Comments |
P.499 right column bottom paragraph: "The HD (Homeodomain) is embedded in proteins that can differ substantially in size. Some proteins are barely larger than the HD itself, e.g., mouse Hopx (73 amino acids) (primary source Kook et al. 2006) or C. elegans CEH-7 (84 amino acids) (primary source Kagoshima et al. 1999), while some are large and contain many other domains, e.g., Arabidopsis Ringlet 1 (AT1G28420, 1705 amino acids), or human ZFHX3 (ATBF1, 3703 amino acids, Sup. Fig. S3)." |
| Entered by |
Uri M |
| ID |
116972 |