| Comments |
P.102 2nd paragraph: "[Investigators] have the opportunity, 3 years and about 25 complete genomes later (Table 1), to assess the original version of the minimal gene set in a fairly comprehensive manner, and [the investigator] do[es] so here, by using the system of clusters of orthologous groups of proteins (COGs) from 21 complete genomes (refs 22, 35, 36)." P.103 bottom paragraph: "The current collection of Clusters of Orthologous Groups of proteins (COGs) shows two striking and, in a sense, opposing trends that are relevant for the discussion of the minimal-gene-set concept (35, link ). First, it is notable that 55%–83% of the proteins encoded in each of the bacterial and archaeal genomes belong to the COGs, which, it should be emphasized, by definition include representatives of at least three phylogenetically distant clades (Table 1)." |