Diameter of phagosomes containing (Salmonella typhimurium) bacteria

Range 3 - 6 µm
Organism Mouse Mus musculus
Reference Alpuche-Aranda CM, Racoosin EL, Swanson JA, Miller SI. Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes. J Exp Med. 1994 Feb 1 179(2):601-8 link p.601 right column bottom paragraph PubMed ID8294870
Primary Source [9] Alpuche Aranda CM, Swanson JA, Loomis WP, Miller SI. Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes. Proc Natl Acad Sci U S A. 1992 Nov 1 89(21):10079-83PubMed ID1438196
Comments P.601 right column bottom paragraph: "[Investigators] noticed during [their] measurements of pH that phagosomes containing bacteria were 3-6 µm in diameter (primary source). These unusually large or spacious phagosomes (SP) were similar in size to macropinosomes, endocytic vesicles formed from plasma membrane ruffles that appear in response to PMA or macrophage colony-stimulating factor (M-CSF) (refs 12, 13)."
Entered by Uri M
ID 116148