Diameter of immortalized (C57BL/6) microglia BV-2 cell

Range without exposure to LPS [lipopolysaccharide] 10-15: after LPS activation 25–30 µm
Organism Mouse Mus musculus
Reference Gibson CJ, Hossain MM, Richardson JR, Aleksunes LM. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J Pharmacol Exp Ther. 2012 Dec343(3):650-60. doi: 10.1124/jpet.112.196543. p.653 right columnPubMed ID22942241
Method Phase-contrast microscopy
Comments P.653 right column: "Morphological changes were confirmed at 6 h with phase-contrast microscopy (Supplemental Fig. 1, A and B). BV-2 cells without exposure to LPS [lipopolysaccharide] were 10 to 15 μm in diameter, uniformly round, with occasional thin cytoplasmic projections. After LPS activation, BV-2 cells were much larger in diameter (25–30 μm), polymorphic, with many exhibiting thick cytoplasmic projections."
Entered by Alex
ID 112783