Concentration of total and free magnesium ion (Mg2+)

Range total 20-100: free 1-2 mM
Organism Bacteria Escherichia coli
Reference Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6663 left column 3rd paragraphPubMed ID24901537
Primary Source [35] Outten CE, O'Halloran TV. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science. 2001 Jun 29 292(5526):2488-92 DOI: 10.1126/science.1060331 [36] Moncany ML, Kellenberger E. High magnesium content of Escherichia coli B. Experientia. 198137(8):846-7 [37] Alatossava T, Jütte H, Kuhn A, Kellenberger E. Manipulation of intracellular magnesium content in polymyxin B nonapeptide-sensitized Escherichia coli by ionophore A23187 J Bacteriol. 1985 Apr162(1):413-9 [38] Tyrrell J, McGinnis JL, Weeks KM, Pielak GJ. The cellular environment stabilizes adenine riboswitch RNA structure. Biochemistry. 2013 Dec 3 52(48):8777-85. doi: 10.1021/bi401207qPubMed ID11397910, 7026272, 2984182, 24215455
Comments P.6663 left column 3rd paragraph: "Similarly, large variations in the total concentration of Mg2+ have been reported, with estimates ranging from 20 (primary source 35) to 100 mM (primary source 36) although the amount of free Mg2+ is estimated to be much smaller in comparison at 1–2 mM (primary sources 37, 38)."
Entered by Uri M
ID 115774