Fraction of driver gene mutations in prostate cancers that can be attributed to DNA replication errors (R)
| Range | 95 % |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017 Mar 24 355(6331):1330-1334. doi: 10.1126/science.aaf9011 p.1332 left column top paragraphPubMed ID28336671 |
| Comments | P.1331 right column bottom paragraph: "A third class of cancers comprise those in which only a very small effect of E (environmental factors) or H (heredity) has been demonstrated (ref 17), such as those of the brain, bone, or prostate. For example, a very high fraction of the driver gene mutations in prostate cancers can be attributed to R (95%, Fig. 2D and supplementary materials)." |
| Entered by | Uri M |
| ID | 115308 |