| Comments |
P.96 right column bottom paragraph: "The second step of glucose uptake is through inner membrane transporters. [Investigators] estimate that glucose transporters occupy only 1% of the membrane area when overflow metabolism begins, and thus make a much smaller contribution to inner membrane crowding than the electron transport chain (Figure 2A and Box 1). This number is obtained using the area of a glucose transporter dimer (48 ± 10 nm^2) (Jeckelmann et al., 2011), its maximum uptake rate (kT=180 ± 40 glucose/s), the surface-to-volume ratio of a cell (Figure 1A), and the cell’s total glucose uptake rate (Vemuri et al., 2006, O’Brien et al., 2013) (Table S1A)." |