Halflife of sodium channel

Range in cultured mouse neuroblastoma cells ~1 day: in rabbit Schwann cells in vitro 2 days days
Organism Mammals
Reference Hildebrand C, Remahl S, Persson H, Bjartmar C. Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar40(3):319-84 p.337 left column top paragraphPubMed ID8441812
Primary Source Waechter CJ, Schmidt JW, Catterall WA. Glycosylation is required for maintenance of functional sodium channels in neuroblastoma cells. J Biol Chem. 1983 Apr 25 258(8):5117-23 AND Ritchie JM. Sodium-channel turnover in rabbit cultured Schwann cells. Proc R Soc Lond B Biol Sci. 1988 May 23 233(1273):423-30.PubMed ID6300116, 2456584
Comments P.337 left column top paragraph: "Alternatively, astrocytic extensions may participate in the catabolism of channel molecules. The half life of sodium channels is about 1 day in cultured neuroblastoma cells, and 2 days in Schwann cells in vitro (primary sources)."
Entered by Uri M
ID 114486