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Observed free energies of folding of proteins (for a typical protein of 100-200 residues)

Range	5 - 15 kcal/mol
Organism	Generic
Reference	Fersht AR. The sixth Datta Lecture. Protein folding and stability: the pathway of folding of barnase. FEBS Lett. 1993 Jun 28 325(1-2):5-16 p.5 left columnPubMed ID8513892
Comments	P.5 left column: "Further, the observed free energies of folding of proteins are very small, at some 5-15 kcal/mol for a typical protein of 100-200 residues. Those small numbers are the differences between two large numbers, the free energies of the non-covalent interactions in the folded and unfolded states, neither of which can be calculated with sufficient precision given the uncertainties in the methods currently used for interactions in solution [refs 3,4]."
Entered by	Uri M
ID	114425