| Comments |
P.4 left column bottom paragraph: "In analogy with the definition of oxidative stress, overproduction of radicals derived from nitrogen (RNS) is termed nitrosative stress. During the inflammatory processes, the immune system produces both the superoxide anion radical and nitric oxide. Under these conditions, these two radical species may react together to from significant amounts of peroxynitrite anion ONOO− (NO· + O2·− → ONOO−), which is a very potent oxidant capable of participating in several oxidative reactions causing DNA fragmentation and oxidation of lipids (Prolo et al. 2015). The reaction of peroxynitrite formation has one of the highest rate constants (~10^10 M^−1×s^−1). Thus, the toxicity of nitric oxide is a consequence of its reactivity with superoxide radical anion to form peroxynitrite." |