| Range |
Figure link
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| Organism |
vertebrates |
| Reference |
Yewdell JW, Reits E, Neefjes J. Making sense of mass destruction: quantitating MHC class I antigen presentation. Nat Rev Immunol. 2003 Dec3(12):952-61. DOI: 10.1038/nri1250 p.957 figure 4PubMed ID14647477
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| Primary Source |
[7] Reits, E. et al. Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity 18, 97–108 (2003) [66] Princiotta, M. F. et al. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity 18, 343–354 (2003).PubMed ID12530979, 12648452
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| Method |
Primary source [7] abstract: "[Investigators] have visualized the fate and dynamics of intracellular peptides in living cells." Primary source [66] abstract: "Using L929 cells [mouse], [investigators] quantitated the macroeconomics of protein synthesis and degradation and the microeconomics of producing MHC class I associated peptides from viral translation products." |
| Comments |
P.959 left column bottom paragraph: "Using a substrate targeted for rapid and complete destruction, the efficiency of antigen processing was found to be one complex generated per 2,000 proteins degraded (Figs 3 and 4). This low efficiency does not seem to be a peculiarity of L929 cells, as professional APCs (bone-marrow-derived dendritic cells and peritoneal macrophages) were equally efficient at peptide generation [primary source 66]." See caption beneath figure |
| Entered by |
Uri M |
| ID |
113774 |