Fraction of newly synthesized proteins that are rapidly degraded
| Range | ~30 % |
|---|---|
| Organism | Unspecified |
| Reference | Glembotski CC. Endoplasmic reticulum stress in the heart. Circ Res. 2007 Nov 9 101(10):975-84. DOI: 10.1161/CIRCRESAHA.107.161273 abstractPubMed ID17991891 |
| Comments | Abstract: "Recent interest has focused on the possibility that the accumulation of misfolded proteins can also contribute to vascular and cardiac diseases. In large part, the misfolding of proteins takes place during synthesis on free ribosomes in the cytoplasm or on endoplasmic reticulum ribosomes. In fact, even under optimal conditions, approximately 30% of all newly synthesized proteins are rapidly degraded, most likely because of improper folding." |
| Entered by | Uri M |
| ID | 113409 |