Fraction of the endogenous proteome that requires additional assistance in folding from the multisubunit chaperonin GroEL

Value 10 %
Organism Bacteria Escherichia coli
Reference Scotto-Lavino E, Bai M, Zhang YB, Freimuth P. Export is the default pathway for soluble unfolded polypeptides that accumulate during expression in Escherichia coli. Protein Expr Purif. 2011 Apr 2 p.1 right column top sentencePubMed ID21443953
Primary Source Kerner MJ, Naylor DJ, Ishihama Y, Maier T, Chang HC, Stines AP, Georgopoulos C, Frishman D, Hayer-Hartl M, Mann M, Hartl FU. Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell. 2005 Jul 29 122(2):209-20.PubMed ID16051146
Comments GroEL concentrations in E. coli cells are sufficient to fold about 5% of total cell protein (Lorimer 1996 PMID 8566548)
Entered by Uri M
ID 106325