| Comments |
P.1242 right column bottom paragraph: "The fact that few p-sites appear as phosphorylated and conserved between the two species is not surprising. It could be attributed to several factors, such as the incompleteness of the p-site compendia of the two species and experimental biases, since the C. albicans compendium was based only on two experiments (Boekhorst et al. 2008, 2011). In a recently published study, [investigators'] group has estimated that the total S. cerevisiae phosphoproteome may be ca. 40,000 p-sites (BNID 113378). Other contributing factors could be the evolutionary distance of ∼300 million years between S. cerevisiae and C. albicans (primary source), the high evolutionary turnover generally observed for p-sites, the fast network rewiring at the phosphorylation-regulatory level, and the relaxed localization constraints for p-site conservation (Iakoucheva et al. 2004, Moses et al. 2007, Landry et al. 2009, 2014, Beltrao et al. 2009, Shou et al. 2011, Freschi et al. 2014)." |