---

Average rate of sequence divergence at synonymous sites in homologous protein coding regions between E. coli and S. enterica

Value	0.9 %/million years
Organism	bacteria
Reference	Kashtan N et al., Single-cell genomics reveals hundreds of coexisting subpopulations in wild Prochlorococcus. Science. 2014 Apr 25 344(6182):416-20. doi: 10.1126/science.1248575. Supplementary material p.26 3rd paragraphPubMed ID24763590
Primary Source	[89] H. Ochman, A. C. Wilson , Evolution in bacteria: Evidence for a universal substitution rate in cellular genomes. J. Mol. Evol. 26, 74–86 (1987). doi:10.1007/BF02111283 [90] H. Ochman, S. Elwyn, N. A. Moran, Calibrating bacterial evolution. Proc. Natl. Acad. Sci. U.S.A. 96, 12638–12643 (1999). doi:10.1073/pnas.96.22.12638PubMed ID3125340, 10535975
Comments	Supplementary material p.26 3rd paragraph: "Comparison of divergence rates with other organisms: This is another useful method for the estimation of divergence times. The average rate of sequence divergence at synonymous sites in homologous protein coding regions between E. coli and S. enterica (primary sources 89, 90) were estimated at 0.9% per million years. If divergence rates within Prochlorococcus are similar it would indicate the cN2 C1-C5 clades shared a common ancestor at least 10 million years ago. Note that the estimated number of generations per year for both E. coli and Prochlorococcus is very similar (100-300 per year) as does the mutation rate (𝜇) (primary source 90)."
Entered by	Uri M
ID	113306