| Comments |
P.3502 left column bottom paragraph: "The total cellular protein concentration typically lies within a range of 20% to 30% (w/v) (i.e. 200 to 300 g/l, BNID 113242) in many cell types and organisms (ref 33). This constraint can be used to convert between cellular protein mass and cell volume. Hepatocytes, the predominant cell type in liver, are roughly cubical cells with a 15-μm edge length (BNID 113236). Assuming a total protein concentration of 200 g/l, this translates to 675 pg of protein per cell. This compares to [investigators'] estimate of 464 ± 35 pg total protein per average liver cell, which is reasonable given that non-hepatocytes contribute the same amount of DNA or histones but less overall protein mass." |