| Comments |
P.179 left column 2nd paragraph to right column top paragraph: "Tissue engineering has attempted to recapitulate the highly differentiated molecular, structural, and functional properties of the heart at various hierarchical scales in vitro. At the centimeter scale, tissue engineering aims for compact constructs of a thickness comparable to that of the human myocardium (~1.5 cm). The main challenge in meeting this requirement is in the high metabolic demand of cardiomyocytes for oxygen (27.6 nmol/mg [protein.min] ref 111) that cannot be met by diffusional supply of oxygen." |