Pathways of RTK [Receptor tyrosine kinases] endocytosis

Range Figure - link
Organism Generic
Reference Goh LK, Sorkin A. Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol. 2013 May 1 5(5):a017459. doi: 10.1101/cshperspect.a017459. p.2 figure 1PubMed ID23637288
Comments P.9 left column top paragraph: "Postendocytic sorting of RTKs: Morphology and pathways- Endocytic carriers formed by CME [clathrin-mediated endocytosis] and CIE [clathrin-independent endocytosis] deliver cargo to EEs [early endosomes] located in the cell periphery. EEs have vesicular and tubular subcompartments-they can fuse to each other while moving along microtubules toward the centriole/Golgi area of the cell (Fig. 1). In the specialized and extreme example of neuronal cells, ligandbound Trk receptors are internalized in the axonal terminal and transported for a long distance in EEs in a microtubule-dependent manner to the neuronal soma. The mechanisms and functions of the retrograde transport of endocytosed neurotrophin receptors were recently reviewed (Wu et al. 2009)." See note beneath figure
Entered by Uri M
ID 112724