| Comments |
P.9 left column top paragraph: "Postendocytic sorting of RTKs:
Morphology and pathways- Endocytic carriers formed by CME [clathrin-mediated endocytosis] and CIE [clathrin-independent endocytosis] deliver cargo to EEs [early endosomes] located in the cell periphery. EEs have vesicular and tubular subcompartments-they can fuse to each other while moving along microtubules toward the centriole/Golgi area of the cell (Fig. 1). In the specialized and
extreme example of neuronal cells, ligandbound Trk receptors are internalized in the axonal terminal and transported for a long distance
in EEs in a microtubule-dependent manner to the neuronal soma. The mechanisms and functions of the retrograde transport of endocytosed
neurotrophin receptors were recently
reviewed (Wu et al. 2009)." See note beneath figure |