Turnover rate for RTK [Receptor Tyrosine Kinases] for cell types see comments section

Range for colony stimulating factor 1 receptor (CSF-1R) <1hour: for EGFR 24hours hours
Organism Mammals
Reference Goh LK, Sorkin A. Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol. 2013 May 1 5(5):a017459. doi: 10.1101/cshperspect.a017459. p.1 right column top paragraphPubMed ID23637288
Primary Source Lee PS, Wang Y, Dominguez MG, Yeung YG, Murphy MA, BowtellDD, Stanley ER. 1999. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J 18: 3616–3628. AND Stoscheck CM, Carpenter G. 1984. Characterization of the metabolic turnover of epidermal growth factor receptor protein in A-431 cells. J Cell Physiol 120: 296–302.PubMed ID10393178, 6086681
Comments P.1 left column: "The rates of the constitutive internalization, recycling, and degradation determine the half-life of an RTK [receptor tyrosine kinases] protein, which varies depending on the nature of the RTK and the cell type, and typically positively correlates with the expression level of the RTK. For example, the turnover rates range from t1/2 < 1 h for the colony stimulating factor 1 receptor (CSF-1R) in macrophages (primary source Lee et al. 1999) to 24 h for the epidermal growth factor receptor (EGFR) overexpressed in carcinoma cells (primary source Stoscheck and Carpenter 1984)." Primary source Lee et al. 1999 studied mice. Primary source Stoscheck and Carpenter 1984 studied human cells (A431 cells, a model human cell line (epidermoid carcinoma))
Entered by Uri M
ID 112723