Fraction of hepatocytes that enter S phase within 24-48 hours after liver injury

Range ~90 %
Organism Unspecified
Reference Hang HL, Xia Q. Role of BMSCs in liver regeneration and metastasis after hepatectomy. World J Gastroenterol. 2014 Jan 720(1):126-32. doi: 10.3748/wjg.v20.i1.126. p.127 left column top paragraphPubMed ID24415865
Comments P.127 left column top paragraph: "After severe liver injury, liver progenitors, known as “oval cells”, are also activated to participate in the regeneration process [ref 2]. As the storage pool of progenitor cells, the bone marrow plays an important role in cellular mobilization during liver regeneration. Within 24-48 h after liver injury, nearly 90% of hepatocytes enter into the S phase of the cell cycle. At this time, DNA replication begins, and various cell factors and growth factors are released through autocrine or paracrine modes of action these factors include epithelial growth factors, hepatocyte growth factors, insulin-like growth factors, vascular endothelial growth factors, tumor necrosis factors and urokinase [ref 3]."
Entered by Uri M
ID 112714