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Without addition of membrane, a lipid bilayer will rupture upon an increase in area of

Range	3 - 5 %
Organism	Unspecified
Reference	Sens P, Plastino J. Membrane tension and cytoskeleton organization in cell motility. J Phys Condens Matter. 2015 Jul 15 27(27):273103. doi: 10.1088/0953-8984/27/27/273103. p.5 right column bottom paragraphPubMed ID26061624
Primary Source	[31] Morris C E and Homann U 2001 Cell surface area regulation and membrane tension J. Membrane Biol. 179 79–102PubMed ID11220366
Comments	P.5 right column bottom paragraph: "During spreading of fibroblasts, membrane area is observed to increase by 80% with the doubling of the cell area in contact with the substrate, and other cell types show similar trends although less dramatic [BNID 112510]. Membrane tensions of unspread and spread cells as measured by tether pulling are identical. Without addition of membrane, a lipid bilayer will rupture upon a 3–5% increase in area, due to excessive membrane tension [primary source]. Something therefore must compensate for the large changes in cell and membrane area required for a cell to spread once membrane folds have been pulled out."
Entered by	Uri M
ID	112511