Increase in membrane area per cell due to disassembly of caveolae

Range ~0.3 %
Organism vertebrates
Reference Sens P, Plastino J. Membrane tension and cytoskeleton organization in cell motility. J Phys Condens Matter. 2015 Jul 15 27(27):273103. doi: 10.1088/0953-8984/27/27/273103. p.5 right column bottom paragraphPubMed ID26061624
Primary Source [41] Sinha B et al 2011 Cells respond to mechanical stress by rapid disassembly of caveolae Cell 144 402–13 doi: 10.1016/j.cell.2010.12.031.PubMed ID21295700
Comments P.5 right column bottom paragraph: "When cells experience an increase in membrane tension, triggered either chemically or mechanically by physically increasing cell area, caveolae are predicted theoretically and observed experimentally to disassemble [refs 40, 42 & primary source]. This is calculated to give approximately a 0.3% increase in membrane area per cell [primary source]." P.6 left column top paragraph: "It is only once thermal fluctuations start to be constrained that tension rises, so that the release of a mere 0.3% of membrane area contained in the 'caveolae reservoir' at this stage can have a large buffering effect on membrane tension. So caveolae may indeed act as a first responder to membrane tension increases by simply flattening out in response to stress."
Entered by Uri M
ID 112512