| Comments |
P.5 right column bottom paragraph: "When cells experience an increase in membrane tension, triggered either chemically or mechanically by physically increasing cell area, caveolae are predicted theoretically and observed experimentally to disassemble [refs 40, 42 & primary source]. This is calculated to give approximately a 0.3% increase in membrane area per cell [primary source]." P.6 left column top paragraph: "It is only once thermal fluctuations start to be constrained that tension rises, so that the release of a mere 0.3% of membrane area contained in the 'caveolae reservoir' at this stage can have a large buffering effect on membrane tension. So caveolae may indeed act as a first responder to membrane tension increases by simply flattening out in response to stress." |