| Value |
1.28E-08
mutations/site/generation
Range: 1.13×10^−8 to 1.43×10^−8 mutations/site/generation
|
| Organism |
Human Homo sapiens |
| Reference |
Rahbari R et al., Timing, rates and spectra of human germline mutation. Nat Genet. 2016 Feb48(2):126-33. doi: 10.1038/ng.3469. p.127 left column top paragraphPubMed ID26656846
|
| Method |
Abstract: "[Investigators] investigated genome-wide mutation rates and spectra in multi-sibling families." |
| Comments |
P.127 left column top paragraph: "Family-specific paternal age effects: [Investigators] sequenced the genomes of three multi-sibling families (Fig. 1). [They] discovered and validated 768 DNMs [de novo mutations] across the three families, with an average of 64 DNMs per child (range of 43–84: Supplementary Table 1). When taking into account genomic regions inaccessible to [their] analyses (Online Methods), the average number of mutations per individual increased to 76.9. This adjusted number of mutations is equivalent to an average mutation rate of 1.28 × 10^−8 (95% confidence interval (CI) = 1.13–1.43 × 10^−8) mutations per nucleotide per generation at a mean paternal age of 29.8 years." |
| Entered by |
Uri M |
| ID |
112459 |