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Affinity of CRP/CAP for cGMP

Range	10-20 µM
Organism	Bacteria Escherichia coli
Reference	Emmer, M., deCrombrugghe, B., Pastan, I., and Perlman, R. (1970). Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. Proc. Natl. Acad. Sci. U. S. A. 66, 480–487. p.483 bottom paragraphPubMed ID4317918
Comments	P.483 bottom paragraph:"Cyclic 3',5'-GMP was the only compound tested which did inhibit cyclic AMP binding. More detailed analysis revealed that this inhibition was competitive (Fig. 1), with an apparent dissociation constant of about 1-2×10^-5 M."
Entered by	Avi Flamholz
ID	112396