Constant for binding of activator CRP to lac promoter activating site

Value 0.02 nM
Organism Bacteria Escherichia coli
Reference Bintu L, Buchler NE, Garcia HG, Gerland U, Hwa T, Kondev J, Phillips R. Transcriptional regulation by the numbers: models. Curr Opin Genet Dev. 2005 Apr15(2):116-24. Fig. 1PubMed ID15797194
Primary Source Wong P, Gladney S, Keasling JD. Mathematical model of the lac operon: inducer exclusion, catabolite repression, and diauxic growth on glucose and lactose. Biotechnol Prog. 1997 Mar-Apr13(2):132-43.PubMed ID9104037
Method A mathematical model of the lactose (lac) operon was developed to study diauxic growth on glucose and lactose. The model includes catabolite repression, inducer exclusion, lactose hydrolysis to glucose and galactose, and synthesis and degradation of allolactose.
Comments This is an in vitro value taken as a representative example.
Entered by Uri M
ID 103591