| Range |
1 - 3 months
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Kushner JA. The role of aging upon β cell turnover. J Clin Invest. 2013 Mar123(3):990-5. doi: 10.1172/JCI64095. p.990 right column bottom paragraphPubMed ID23454762
|
| Primary Source |
[20] Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of β-cell mass in the growing rat pancreas. Diabetes. 1995 44(3):249–256.PubMed ID7883109
|
| Method |
Primary source abstract:"...[investigators] first mathematically analyzed the data available on the components involved in the maintenance of beta-cell mass, including rates of replication, beta-cell volume, and the beta-cell mass itself, at various ages in normal Sprague-Dawley rats. Then these data were combined in a simple mass balance equation to construct a mathematical model of the dynamics of the beta-cell mass in the normal growing rat pancreas." |
| Comments |
P.990 right column bottom paragraph:"Although rodent β cells have traditionally been thought to undergo frequent turnover, recent studies suggest that cell cycle entry of β cells may be severely limited in advanced age. A highly cited thymidine analog–labeling study by Finegood, Scaglia, and Bonner-Weir reported that β cells replicated every 1–3 months in young rats (primary source)." |
| Entered by |
Uri M |
| ID |
112318 |