Velocities of axonal transport in Pike olfactory nerve

Range Table - link
Organism Fish
Reference Weiss DG & Buchner VE, chapter 10, Axoplasmic transport in olfactory receptor neurons, pp.217-236 in Frank L. Margolis, Thomas V. Getchell, eds. Molecular Neurobiology of the Olfactory System: Molecular, Membranous, and Cytological Studies, Plenum Press 1988th Edition p.224 table 1
Primary Source Buchner, K., 1986, Vergleich von anterogradem und retrogradem und retrogradem axonalen transport im riechnerv des hechtes, Ph.D. thesis, University Munich, Federal Republic of Germany & Buchner, K. et al., 1987, A quantitative study of anterograde and retrograde axoplasmic transport of exogenous proteins in olfactory nerve C-fibers, Neuroscience 22: 697-707 & Buchner, K. et al., Bidirectional movement of large organelles in very thin axons: An EM and AVEC-DIC study (in preparation) & Gross, G. W., and Kreutzberg, G. W., 1978, Rapid axoplasmic transport in the olfactory nerve of the pike. I. Basic transport parameters for proteins and amino acids, Brain Res. 139: 65-76 & Schmid, G. et al., 1983, Rapid axoplasmic transport of free leucine, J. Neurobiol. 14: 133-144 & Weiss, DG., 1982, 3-O-methyl-D-glucose and β-alanine: Rapid axoplasmic transport of metabolically inert low molecular weight substances, Neurosci. Lett. 31: 241-246PubMed ID3670606, 74275, 6188802, 6182511
Comments P.222 bottom paragraph:"Following injection of 3H-labeled leucine into the nerve proper, bidirectional transport of free leucine can be observed (Fig. 6). The velocities (Vmax) were similar for both directions (36 mm/day anterogradely and 46 mm/day, retrogradely)(primary source Buchner, 1986), but considerably slower than the anterograde transport of free leucine taken up into the perikarya in the olfactory mucosa (cf. Table 1)(primary sources Gross and Kreutzberg, 1978 Schmid et al., 1983). This difference in transport velocity is not understood. Since labeled inulin, a marker of the extracellular space, is not transported and colchicine inhibits free amino acid transport, it was concluded to be an intracellular phenomenon. Also retrograde transport of free leucine was found to exist and to be inhibited by colchicine (Fig. 6)."
Entered by Uri M
ID 112194