| Range |
<0.1 %
|
| Organism |
Unspecified |
| Reference |
Bahar Halpern K. et al., Bursty gene expression in the intact mammalian liver. Mol Cell. 2015 Apr 2 58(1):147-56. doi: 10.1016/j.molcel.2015.01.027. p.147 right column 2nd paragraphPubMed ID25728770
|
| Primary Source |
A.W. Duncan Aneuploidy, polyploidy and ploidy reversal in the liver, Semin. Cell Dev. Biol., 24 (2013), pp. 347–356 doi: 10.1016/j.semcdb.2013.01.003.PubMed ID23333793
|
| Comments |
P.147 right column 2nd paragraph:"Fewer than 0.1% of hepatocytes are cycling at any given time (primary source), and so the contribution of cell-cycle stage to gene expression variability in the liver can be neglected. Assessing intrinsic variability among hepatocytes must take into account the key sources of heterogeneity in this tissue and focus on expression differences between cells of identical ploidy residing at the same spatial zone." See Fausto & Campbell 2003 PMID 12490302 [primary source of Duncan 2013] p.123 right column bottom paragraph:"Regeneration of the liver after PH [partial hepatectomy] or models of regeneration that combine PH and cell injury are very rapid processes that differ from the very slow hepatocyte turnover in normal adult liver. Rates of hepatocyte DNA labeling and apoptosis are very low in the normal liver (less than 0.1%) and are thus difficult to estimate with accuracy." |
| Entered by |
Uri M |
| ID |
112171 |