| Comments |
P.147 right column 2nd paragraph:"The liver consists of a mixture of hepatocytes with either one or two nuclei, where each nucleus has 2, 4, 8, or 16 copies of each chromosome. Thus, the liver is composed of multiple sub-populations distinguished by ploidy and tissue location." p.152 left column bottom paragraph:"Hepatocyte Polyploidy Reduces Gene Expression Noise: Unlike most tissues in our body, which consist of mono-nucleated cells with diploid genomes, the liver is a polyploid tissue, consisting of hepatocytes with either one or two nuclei where each nucleus has either two, four, eight, or 16 copies of each chromosome. This feature is highly ubiquitous with more than ∼85% of hepatocytes harboring more than two genomic copies in the tissues studied (15% diploids, 75% tetraploids, and 8% octoploids). The functional advantages of liver polyploidy remain unclear. [Investigators’] observation of independent promoter bursting (Figure S4) suggested that polyploidy could serve as an additional mechanism to reduce burst-associated noise." |