CA1 pyramidal cells firing rate in vivo

Range at rest 1Hz: during activity 5-20Hz Hz
Organism Rat Rattus norvegicus
Reference Waters, J. and Smith, S.J (2002) Vesicle pool partitioning influences presynaptic diversity and weighting in rat hippocampal synapses. J. Physiol., 541(Pt 3):811-23. p.811 left column bottom paragraphPubMed ID12068042
Primary Source Wiener, S. I., Paul, C. A. & Eichenbaum, H. (1989). Spatial and behavioural correlates of hippocampal neuronal activity. Journal of Neuroscience 9, 2737–2763. AND Czurkó, A., Hirase, H., Csicsvari, J. & Buzsáki, G. (1999). Sustained activity of hippocampal pyramidal cells by ‘space clamping’ a running wheel. European Journal of Neuroscience 11, 344–352. AND Hirase, H., Czurkó, A., Csicsvari, J. & Buzsáki, G. (1999). Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal of Neuroscience 11, 4373–4380.PubMed ID2769364, 9987037, 10594664
Comments p.811 left column bottom paragraph:"Most functional studies of hippocampal synaptic properties have examined release in response to single stimuli or low-frequency trains (0.5 Hz). Although single unit recordings in vivo indicate that CA1 pyramidal cells fire at approximately 1 Hz at rest, during activity (such as running in a wheel) the firing rate increases to 5-20 Hz and may be sustained throughout the duration of the activity (primary sources)."
Entered by Uri M
ID 112031