| Range |
synaptic vesicle fraction >400: clathrin-coated vesicle ~200: synaptosome >3,000 different proteins
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| Organism |
Unspecified |
| Reference |
O'Rourke NA, Weiler NC, Micheva KD, Smith SJ. Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci. 2012 May 10 13(6):365-79. doi: 10.1038/nrn3170. p.367 left column top paragraphPubMed ID22573027
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| Primary Source |
[3] Takamori, S. et al. Molecular anatomy of a trafficking organelle. Cell 127, 831–846 (2006). [4] McPherson, P. S. Proteomic analysis of clathrin-coated vesicles. Proteomics 10, 4025–4039 (2010). doi: 10.1002/pmic.201000253. [8] Schrimpf, S. P. et al. Proteomic analysis of synaptosomes using isotope-coded affinity tags and mass spectrometry. Proteomics 5, 2531–2541 (2005). [9] Filiou, M. D. et al. Profiling of mouse synaptosome proteome and phosphoproteome by IEF. Electrophoresis 31, 1294–1301 (2010). doi: 10.1002/elps.200900647.PubMed ID17110340, 21080493, 15984043, 20309889
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| Comments |
p.366 right column bottom paragraph to p.367 left column top paragraph:"Although technical limitations preclude certainty as to the total number of protein species composing any single synapse, proteomic studies in rodent brain using subcellular fractionation and large-scale mass spectrometry have provided extensive lists of protein species found in various synaptic fractions. Synaptic vesicle fractions contain over 400 protein species [primary source 3], clathrin-coated vesicles about 200 [primary source 4], PSDs [postsynaptic densities] from 200 to over 1,000 species [BNID 112018] and synaptosomes more than 3,000 [primary sources 8,9]." Primary sources 3, 4, 8 & 9 investigated rat, unknown organism, mouse & mouse, respectively. |
| Entered by |
Uri M |
| ID |
112019 |