Number of proteins that function in the presynaptic nerve terminal

Range >1,000 proteins
Organism Unspecified
Reference Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci. 2004 27: 509-47. p.510 bottom paragraphPubMed ID15217342
Comments "A major goal in neurobiology in recent years has been to gain insight into the molecular machinery that mediates neurotransmitter release. More than 1000 proteins function in the presynaptic nerve terminal, and hundreds are thought to participate in exocytosis. In this protein zoo, which proteins are actually important, and which are only bystanders? How do proteins collaborate in shaping the vesicle cycle, and how can [researchers] understand the functions of so many proteins?"
Entered by Uri M
ID 111279