Degradation half-life of rapidly degrading acetylcholine receptor (AChR) synthesized in denervated and aneural embryonic muscle
| Range | ~1 day |
|---|---|
| Organism | vertebrates |
| Reference | Xu R, Salpeter MM. Rate constants of acetylcholine receptor internalization and degradation in mouse muscles. J Cell Physiol. 1999 Oct181(1):107-12. p.107 left column bottom paragraphPubMed ID10457358 |
| Primary Source | Levitt TA, Loring RH, Salpeter MM. 1980. Neuronal control of acetylcholine receptor turnover rate at a vertebrate neuromuscular junction. Science 210: 550–551 & Levitt TA, Salpeter MM. 1981. Denervated endplates have a dual population of junctional acetylcholine receptors. Nature 291:239–241 & Reiness CG, Weinberg CB. 1981. Metabolic stabilization of acetylcholine receptors at newly formed neuromuscular junctions in rat. Dev Biol 84: 247–254 & Shyng S-L, Salpeter MM. 1989. Degradation rate of acetylcholine receptors inserted into denervated vertebrate neuromuscular junctions. J Cell Biol 108: 647–651 & Shyng S-L, Salpeter MM. 1990. Effect of reinnervation on the degradation rate of junctional acetylcholine receptors synthesized in denervated skeletal muscles. J. Neuroscience 10(12): 3905–3915PubMed ID7423205, 7231540, 20737862, 2918028, 2269890 |
| Comments | p.107 left column bottom paragraph:"Two populations of AChRs, differing in their degradation rate and in their responses to stabilizing factors, exist in vertebrate muscle. These are the slowly degrading (Rs) and the rapidly degrading (Rr). Rs AChRs are synthesized in adult innervated muscles and inserted at the neuromuscular junction (nmj). As long as the muscle remains innervated, they degrade slowly with a half-life (t1/2) of ~8–10 days (reviewed in Salpeter and Loring, 1985). Rr AChRs are the predominant (~90%) receptor population synthesized in denervated and aneural embryonic muscle and normally degrade rapidly with a t1/2 of ~1 day (primary sources)." |
| Entered by | Uri M |
| ID | 111880 |