Density of endplate acetylcholine receptors (AChRs) in end plate

Range ~10,000 AChRs/µm^2
Organism vertebrates
Reference Sine SM. End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease. Physiol Rev. 2012 Jul92(3):1189-234. doi: 10.1152/physrev.00015.2011 p.1190 left columnPubMed ID22811427
Primary Source [117] Heuser JE, Salpeter SR. Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane. J Cell Biol. 1979 Jul82(1):150-73 [149] Land BR, Salpeter EE, Salpeter MM. Acetylcholine receptor site density affects the rising phase of miniature endplate currents. Proc Natl Acad Sci U S A. 1980 Jun77(6):3736-40PubMed ID479296, 6932045
Method Electron microscopy and microelectrode recording
Comments P.1189 right column bottom paragraph: "The endplate AChR from skeletal muscle has become an exemplar member of the Cys-loop receptor superfamily owing to both its inherent biological properties and its technical advantages. Endplate AChRs localize opposite motor nerve terminals and aggregate at a density of some 10,000/μm^2 (primary sources), enabling detection by electron microscopy and microelectrode recording." Primary source [117] studied Pacific electric ray (Torpedo californica) or Brazilian electric ray (Narcine braziliensis) and primary source [149] studied lizard (Anolis carolinensis)
Entered by Uri M
ID 115067