| Range |
mitochondria (using the citric acid cycle followed by oxidative phosphorylation) ~93: glycolysis ~7 %
|
| Organism |
Unspecified |
| Reference |
Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.769 left column 2nd paragraphPubMed ID22958818
|
| Primary Source |
Sokoloff, L. (1960). The metabolism of the central nervous system in vivo. In Handbook of Physiology, Section I, Neurophysiology, Volume 3, J. Field, H.W. Magoun, and V.E. Hall, eds. (Washington D.C.: American Physiological Society), pp. 1843–1864. |
| Comments |
p.769 left column 2nd paragraph:"The previous sections assessed how synapse properties can maximize the information that synapses transmit while reducing the energy used. But how is the massive energy use of synapses sustained? Averaged over time, in the adult brain ATP is almost entirely generated by the complete oxidation of glucose. Glycolysis followed by oxidative phosphorylation results in a ratio of oxygen to glucose consumption of nearly 6:1, and mitochondria (using the citric acid cycle followed by oxidative phosphorylation) provide ~93% of the ATP generated (primary source), with only ~7% coming from glycolysis. Consistent with this, mitochondria are preferentially localized to pre- and postsynaptic sites where ATP is consumed (Wong-Riley, 1989 Chang et al., 2006). Nevertheless, when neuronal activity increases during perceptual tasks like those used in functional imaging experiments, which increase energy consumption by only a small percentage (Schölvinck et al., 2008 Lin et al., 2010), it has been suggested that ATP might be generated preferentially by glycolysis." |
| Entered by |
Uri M |
| ID |
111657 |