Number of AMPA receptors opened by a single vesicle

Range 10 - 70 AMPA receptors
Organism Rat Rattus norvegicus
Reference Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.767 left column bottom paragraphPubMed ID22958818
Primary Source Hestrin, S. (1992). Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex. Neuron 9, 991–999. & Silver, R.A., Cull-Candy, S.G., and Takahashi, T. (1996). Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. J. Physiol. 494, 231–250. & Spruston, N., Jonas, P., and Sakmann, B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J. Physiol. 482, 325–352.PubMed ID1384578, 8814618, 7536248
Method Electrophysiology
Comments p.767 left column bottom paragraph:"At different synapses, electrophysiology suggests that 10–70 AMPA receptors are opened by a single vesicle (primary sources), while immunogold labels 8–40 postsynaptic AMPA receptors (Nusser et al., 1998)." AMPA receptor=a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
Entered by Uri M
ID 111653