Number of AMPA receptors opened by a single vesicle
| Range | 10 - 70 AMPA receptors |
|---|---|
| Organism | Rat Rattus norvegicus |
| Reference | Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron. 2012 Sep 6 75(5):762-77. doi: 10.1016/j.neuron.2012.08.019. p.767 left column bottom paragraphPubMed ID22958818 |
| Primary Source | Hestrin, S. (1992). Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex. Neuron 9, 991–999. & Silver, R.A., Cull-Candy, S.G., and Takahashi, T. (1996). Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. J. Physiol. 494, 231–250. & Spruston, N., Jonas, P., and Sakmann, B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J. Physiol. 482, 325–352.PubMed ID1384578, 8814618, 7536248 |
| Method | Electrophysiology |
| Comments | p.767 left column bottom paragraph:"At different synapses, electrophysiology suggests that 10–70 AMPA receptors are opened by a single vesicle (primary sources), while immunogold labels 8–40 postsynaptic AMPA receptors (Nusser et al., 1998)." AMPA receptor=a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor |
| Entered by | Uri M |
| ID | 111653 |