ompA mRNA halflife

Value 15 min
Organism Bacteria Escherichia coli
Reference Mackie GA RNase E: at the interface of bacterial RNA processing and decay. Nat Rev Microbiol. 2013 Jan11(1):45-57. doi: 10.1038/nrmicro2930. p.49 right column 2nd paragraphPubMed ID23241849
Primary Source Emory, S. A., Bouvet, P. & Belasco, J. G. A. 5?-terminal stem loop structure can stabilize mRNA in Escherichia coli. Genes Dev. 6, 135–148 (1992).PubMed ID1370426
Method Primary source abstract:"To elucidate the structural basis of differential mRNA stability in bacteria, the domains of the ompA 5'-untranslated region that allow it to protect mRNA from degradation have been identified by mutational analysis."
Comments "Thus, in E. coli, typical mRNA half-lives (determined by northern blotting or RNase protection) are 60–120 seconds, although a few mRNAs (for example, ompA) display half-lives of up to 15 minutes [primary source]."
Entered by Uri M
ID 111535