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Standard redox potential of glutathione

Range	-240 mV
Organism	Unspecified
Reference	Morgan B, Sobotta MC, Dick TP. Measuring E(GSH) and H2O2 with roGFP2-based redox probes. Free Radic Biol Med. 2011 Dec 1 51(11):1943-51. doi: 10.1016/j.freeradbiomed.2011.08.035. p.1943 right column bottom paragraphPubMed ID21964034
Primary Source	Ostergaard, H. Tachibana, C. Winther, J. R. Monitoring disulfide bond formation in the eukaryotic cytosol. J. Cell Biol. 166: 337–345 2004. & Hwang, C. Sinskey, A. J. Lodish, H. F. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257:1496–1502 1992. & Grant, C. M. MacIver, F. H. Dawes, I. W. Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae. Curr. Genet. 29 :511–515 1996.PubMed ID15277542, 1523409, 8662189
Comments	"Glutathione is the major cellular redox buffer, because of its low standard redox potential (-240 mV) and high cellular concentration (1– 13mM) [primary sources]. There is a large published literature relating to glutathione homeostasis in many model systems. Despite this, many aspects of glutathione homeostasis are still not well understood at a fundamental level."
Entered by	Uri M
ID	111463