Life span of taste bud cell in tongue

Value 250 hours Range: ±50 hours
Organism Rat Rattus norvegicus
Reference Beidler LM, Smallman RL. Renewal of cells within taste buds. J Cell Biol. 1965 Nov27(2):263-72. abstract & p.269 left column top paragraphPubMed ID5884625
Method "...the functional anatomy of the taste bud was investigated using the techniques of colchicine inhibition of mitosis, electrophysiology, and radioautography."
Comments "At 50, 100, and 200 hours, after injection of lsotope, the radioautograms indicate a general migration of the labeled cells toward the center of the taste bud, as shown in Fig. 4, although many cells never reach the center before they degenerate. At 400 hours after injection the tritiated thymidine in most, but not all, of the taste buds appears as spots scattered throughout the taste bud but not associated with any cell nucleus. Several such studies of entrance and disappearance of labeled cells within the taste buds were undertaken and all indicated that the average life span of a taste bud cell is about 250±50 hours."
Entered by Uri M
ID 111427