| Range |
Transcription 1:60,000 - 1:120,000 wrong/correct nucleotides: translation ≥1:3,000 wrong/correct aa
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Ulrich Stelzl,
Sean Connell,
Knud H Nierhaus,
Brigitte Wittmann-Liebold, Ribosomal Proteins: Role in Ribosomal Functions, 2001, DOI: 10.1038/npg.els.0000687, p.1 left column bottom paragraph and right column top paragraph |
| Comments |
p.1 left column bottom paragraph and right column top paragraph:"Ribosomes consist of a small number (3 or 4) of large
rRNA molecules (5S–28S rRNA with 120 to about 4500
nucleotides) and a large number (50–80) of small proteins
(r-proteins with typically 25–300 amino acids). The fact
that ribosomal proteins are short in comparison to the long
rRNA molecules is thought to be related to the high
accuracy of transcription compared to translation. The
transcription accuracy is in the order of 1:60 000 to
1:120 000 (one wrong nucleotide per 120 000 incorporated nucleotides) and this allows the synthesis of accurate
rRNAs of 3000 to 5000 nucleotides without problems,
whereas the translational accuracy is not better than
1:3000. Thus proteins should be composed of fewer amino
acids than rRNA of nucleotides in order to allow the
synthesis of accurate ribosomal proteins. During formation
of functional ribosomes, correctly synthesized r-proteins
are selected by the assembly process." Corresponding to transcriptional error rate of 8.3e-6/nuc - 1.7e-5/nuc, translational error rate of =3.3e-4/aa [aa=amino acid] |
| Entered by |
Uri M |
| ID |
111267 |