| Range |
~50 Hz
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Kress GJ, Mennerick S. Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience. 2009 Jan 12 158(1):211-22. doi: 10.1016/j.neuroscience.2008.03.021. p.213 left column 2nd paragraphPubMed ID18472347
|
| Primary Source |
Hausser M, Roth A (1997) Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells. J Physiol (Lond) 501: 77–95. & Smith SL, Otis TS (2003) Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade. J Neurosci 23:367–372.PubMed ID9174996, 12533595
|
| Comments |
"Many neurons capable of firing sustained, high-frequency
trains (fast-spiking neurons) possess substantial
resurgent sodium currents (Raman and Bean, 1997,
1999). This includes cerebellar Purkinje neurons, with
spontaneous firing rates of ~50 Hz (primary sources). Resurgent sodium currents
are voltage-dependent and tetrodotoxin sensitive. Channels
open briefly and then become blocked by a voltagedependent,
open-channel blocker that unbinds rapidly at
negative potentials (Raman and Bean, 2001)." |
| Entered by |
Uri M |
| ID |
111175 |