| Value |
400
µm^2/sec
|
| Organism |
Lizard Anolis carolinensis |
| Reference |
Land BR, Harris WV, Salpeter EE, Salpeter MM. Diffusion and binding constants for acetylcholine derived from the falling phase of miniature endplate currents. Proc Natl Acad Sci U S A. 1984 Mar81(5):1594-8. abstractPubMed ID6584895
|
| Method |
"[Researchers] recorded MEPCs [miniature endplate currents] by voltage clamp from the intercostal
muscle of the lizard Anolis carolinensis, using experimental
techniques as in the first two papers of this series (1, 2) with
minor modifications." |
| Comments |
"[Researchers] find diffusion to be 4×10^-6cm^2/sec, slightly slower than free diffusion, forward binding to be 3.3×10^7M^-1 s^-1, and the distance from an average release site to the nearest exit from the cleft to be 1.6µm...The diffusion rate constant is somewhat smaller than that
for free diffusion [given as 6-10×10^-6cm^2/Sec (refs 28-30)]." |
| Entered by |
Uri M |
| ID |
111076 |