| Range |
~1 μm^2/sec
|
| Organism |
Metazoa animals |
| Reference |
Keren K et al., Mechanism of shape determination in motile cells. Nature. 2008 May 22 453(7194):475-80. doi: 10.1038/nature06952. Supplementary information p.13 3rd paragraphPubMed ID18497816
|
| Primary Source |
Sheetz, M. P., Sable, J. E., and Dobereiner, H. G., Continuous membranecytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. Annu Rev Biophys Biomol Struct 35, 417 (2006).PubMed ID16689643
|
| Comments |
"The simplest interpretation of [researchers'] observation that cell area fluctuates only ~1% on the scale of seconds to an hour is that the membrane is pulled taut around the
lamellipodium and cell body, and there is very slow exchange of membrane between the exterior cell membrane and its intracellular stores. Indeed, in motile fibroblasts, the endo/exocytosis rate is ~1µm^2/s [primary source], so about an hour would be needed to replace the
plasma membrane thus it is possible that on the seconds-to-minutes time scale a motile keratocyte keeps cell area constant mechanically." |
| Entered by |
Uri M |
| ID |
110898 |