Fraction of T-cell acute lymphoblastic leukemias that are mutated in the Notch pathway

Range >50 %
Organism Human Homo sapiens
Reference Altman BJ, Dang CV. Normal and cancer cell metabolism: lymphocytes and lymphoma. FEBS J. 2012 Aug279(15):2598-609. doi: 10.1111/j.1742-4658.2012.08651.x. p.2601 right column bottom paragraphPubMed ID22672505
Primary Source Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT & Aster JC (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269–271.PubMed ID15472075
Comments "Cancer cells mimic the activated state of lymphocytes by expressing mutated forms of growth factor receptors or other components of the receptor signaling pathways. For instance, the Notch pathway is critical in early B-cell and T-cell development and lineage selection [ref 60], and, not coincidentally, is mutated in > 50% of T-cell acute lymphoblastic leukemias [primary source]."
Entered by Uri M
ID 110713