| Range |
>1 substitution/105 nts/day
|
| Organism |
Virus Microviridae spp. |
| Reference |
Minot S, Bryson A, Chehoud C, Wu GD, Lewis JD, Bushman FD. Rapid evolution of the human gut virome. Proc Natl Acad Sci U S A. 2013 Jul 23 110(30):12450-5. doi: 10.1073/pnas.1300833110. p.12452 right column 2nd paragraphPubMed ID23836644
|
| Method |
"Longitudinal Base Substitution in Viral Contigs: The depth of sequence
information available and the quality of the viral contigs allowed a detailed assessment of the rates of accumulation of base substitutions. For each viral contig at each time point, the extent of nucleotide polymorphism was determined by aligning
reads within each sample. The extent of nucleotide substitution then was compared for each contig between time points, and substitution frequencies were correlated with biological features." |
| Comments |
"The four contigs with the highest rate of nucleotide substitution
were all members of the Microviridae (Fig. 3A). The main variant
for each lineage showed 1–4% nucleotide substitutions over the
course of the experiment (more than one substitution per 105 nt
per day). An alternative explanation for these high substitution
rates could be the immigration of new closely related Microviridae
into the community...Microviridae lineages showed up to 4% substitution in
the main variant over the 2.5-y period studied, consistent with
laboratory experiments also showing high mutation rates for
Microviridae (ref 39)." |
| Entered by |
Uri M |
| ID |
110709 |