Diameter of volume within which chromatin loci diffuse
| Range | ~0.5 µm |
|---|---|
| Organism | Budding yeast Saccharomyces cerevisiae |
| Reference | Oeffinger M, Zenklusen D. To the pore and through the pore: a story of mRNA export kinetics. Biochim Biophys Acta. 2012 Jun1819(6):494-506. doi: 10.1016/j.bbagrm.2012.02.011. p.498 left column 2nd paragraphPubMed ID22387213 |
| Primary Source | 72) P. Heun, T. Laroche, K. Shimada, P. Furrer, S.M. Gasser, Chromosome dynamics in the yeast interphase nucleus, Science 294 (2001) 2181–2186. (73) A. Berger, G. Cabal, E. Fabre, T. Duong, H. Buc, U. Nehrbass, et al., High-resolution statistical mapping reveals gene territories in live yeast, Nat. Methods 5 (2008) 1031–1037. (74) A. Taddei, H. Schober, S.M. Gasser, The budding yeast nucleus, Cold Spring Harb. Perspect. Biol. 2 (2010) a000612.PubMed ID11739961, 18978785, 20554704 |
| Comments | "In yeast, chromatin is very mobile and most loci diffuse within a volume of around 0.5µm in diameter [primary sources]. This suggests that almost any gene can encounter the nuclear periphery passively once in a while to stay in close proximity to a nuclear pore, it simply would have to be tethered there by a factor that mediates the interaction between specific chromatin-associated factors and NPC [nuclear pore complex] components." |
| Entered by | Uri M |
| ID | 110674 |