Diameter of volume within which chromatin loci diffuse

Range ~0.5 µm
Organism Budding yeast Saccharomyces cerevisiae
Reference Oeffinger M, Zenklusen D. To the pore and through the pore: a story of mRNA export kinetics. Biochim Biophys Acta. 2012 Jun1819(6):494-506. doi: 10.1016/j.bbagrm.2012.02.011. p.498 left column 2nd paragraphPubMed ID22387213
Primary Source 72) P. Heun, T. Laroche, K. Shimada, P. Furrer, S.M. Gasser, Chromosome dynamics in the yeast interphase nucleus, Science 294 (2001) 2181–2186. (73) A. Berger, G. Cabal, E. Fabre, T. Duong, H. Buc, U. Nehrbass, et al., High-resolution statistical mapping reveals gene territories in live yeast, Nat. Methods 5 (2008) 1031–1037. (74) A. Taddei, H. Schober, S.M. Gasser, The budding yeast nucleus, Cold Spring Harb. Perspect. Biol. 2 (2010) a000612.PubMed ID11739961, 18978785, 20554704
Comments "In yeast, chromatin is very mobile and most loci diffuse within a volume of around 0.5µm in diameter [primary sources]. This suggests that almost any gene can encounter the nuclear periphery passively once in a while to stay in close proximity to a nuclear pore, it simply would have to be tethered there by a factor that mediates the interaction between specific chromatin-associated factors and NPC [nuclear pore complex] components."
Entered by Uri M
ID 110674